Nature Communications (Apr 2021)
Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity
- Cheryl Q. E. Lee,
- Baptiste Kerouanton,
- Sonia Chothani,
- Shan Zhang,
- Ying Chen,
- Chinmay Kumar Mantri,
- Daniella Helena Hock,
- Radiance Lim,
- Rhea Nadkarni,
- Vinh Thang Huynh,
- Daryl Lim,
- Wei Leong Chew,
- Franklin L. Zhong,
- David Arthur Stroud,
- Sebastian Schafer,
- Vinay Tergaonkar,
- Ashley L. St John,
- Owen J. L. Rackham,
- Lena Ho
Affiliations
- Cheryl Q. E. Lee
- Institute of Medical Biology, A*STAR
- Baptiste Kerouanton
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Sonia Chothani
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Shan Zhang
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Ying Chen
- Institute of Molecular and Cell Biology, A*STAR
- Chinmay Kumar Mantri
- Duke-NUS Medical School, Program in Emerging Infectious Diseases
- Daniella Helena Hock
- Department of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne
- Radiance Lim
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Rhea Nadkarni
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Vinh Thang Huynh
- Institute of Molecular and Cell Biology, A*STAR
- Daryl Lim
- Genome Institute Singapore, A*STAR
- Wei Leong Chew
- Genome Institute Singapore, A*STAR
- Franklin L. Zhong
- Nanyang Technological University, Skin Diseases and Wound Repair Program
- David Arthur Stroud
- Department of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne
- Sebastian Schafer
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Vinay Tergaonkar
- Institute of Molecular and Cell Biology, A*STAR
- Ashley L. St John
- Duke-NUS Medical School, Program in Emerging Infectious Diseases
- Owen J. L. Rackham
- Duke-NUS Medical School, Program in Cardiovascular and Metabolic Disorders
- Lena Ho
- Institute of Medical Biology, A*STAR
- DOI
- https://doi.org/10.1038/s41467-021-22397-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 22
Abstract
Mito-SEPs are small peptides that can modulate oxidative metabolism in mitochondria. Here the authors show that C15ORF48 encodes a mito-SEP, MOCCI, capable of altering mitochondria respiration to suppress inflammation, while C15ORF48 3’ untranslated region also contains a miRNA, miR-147b, that synergizes with MOCCI to modulate host anti-viral responses.
