Green Chemistry Letters and Reviews (Jan 2017)

Synthesis of dihydropyrano[4,3-b]pyranes via a multi-component reaction catalyzed by lipase

  • Xiao Chen,
  • Weian Zhang,
  • Fengjuan Yang,
  • Chao Guo,
  • Ziyuan Zhao,
  • Di Ji,
  • Fan Zhou,
  • Zhi Wang,
  • Rui Zhao,
  • Lei Wang

DOI
https://doi.org/10.1080/17518253.2017.1285442
Journal volume & issue
Vol. 10, no. 1
pp. 54 – 58

Abstract

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A green method for the synthesis of dihydropyrano[4,3-b]pyranes via a three-component reaction catalyzed by lipase is reported firstly. Under the optimal conditions, high yields of dihydropyrano[4,3-b]pyranes (80.8–96.8%) could be obtained in this enzymatic reaction. This study not only expands the application of lipase in organic synthesis, but also provides an alternative efficient method for the synthesis of dihydropyrano[4,3-b]pyranes.

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