Nature Communications (Dec 2020)

Muscle progenitor specification and myogenic differentiation are associated with changes in chromatin topology

  • Nan Zhang,
  • Julen Mendieta-Esteban,
  • Alessandro Magli,
  • Karin C. Lilja,
  • Rita C. R. Perlingeiro,
  • Marc A. Marti-Renom,
  • Aristotelis Tsirigos,
  • Brian David Dynlacht

DOI
https://doi.org/10.1038/s41467-020-19999-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Chromatin structure and topology play important roles in the regulation of gene expression. Here the authors study the spatio-temporal re-organization of promoter-enhancer interactions in pluripotent ES and skeletal muscle stem cells and the corresponding impact on gene expression as a consequence of myogenic commitment and differentiation.