Analytical Cellular Pathology (Jan 2013)

Study on Interaction of Cationic Porphyrazine with Synthetic Polynucleotides

  • Hamid Dezhampanah,
  • Soghra Fyzolahjani

DOI
https://doi.org/10.3233/ACP-140086
Journal volume & issue
Vol. 36, no. 5-6
pp. 125 – 132

Abstract

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Interactions of cationic tetrakis (N, N′, N″, N‴- tetramethyltetra-3, 4-pyridinoporphyrazinatozinc (II) (Zn (tmtppa)) with synthetic polynucleotides, poly (G-C) and poly (A-T), and calf thymus DNA have been characterized in 7.5 mM phosphate buffer of pH 7.2 by UV-Vis absorption and fluorescence spectroscopy. The appearance of hypochromicity more than 30% in UV-Vis spectra of porphyrazine due to interaction of both poly (G-C) and poly (A-T) indicates interaction similar to that of porphyrazine with DNA.