Frontiers in Immunology (Jul 2024)
Successfully treated with siltuximab and prednisone in a 7-year-old girl with DOCK8-deficiency presenting as recurrent wart-like lesions: a case report
- Zhe Sun,
- Zhe Sun,
- Zhe Sun,
- Zhe Sun,
- Ruoqu Wei,
- Ruoqu Wei,
- Ruoqu Wei,
- Ruoqu Wei,
- Chaolan Pan,
- Chaolan Pan,
- Chaolan Pan,
- Chaolan Pan,
- Cheng Ni,
- Cheng Ni,
- Cheng Ni,
- Cheng Ni,
- Xue Zhang,
- Xue Zhang,
- Xue Zhang,
- Xue Zhang,
- Wenbin Guan,
- Ruhong Cheng,
- Ruhong Cheng,
- Ruhong Cheng,
- Ruhong Cheng,
- Yan Gu,
- Yan Gu,
- Yan Gu,
- Yan Gu,
- Hong Yu,
- Hong Yu,
- Hong Yu,
- Hong Yu,
- Kejun He,
- Zhen Zhang,
- Zhen Zhang,
- Zhen Zhang,
- Zhen Zhang,
- Xia Yu,
- Xia Yu,
- Xia Yu,
- Xia Yu,
- Zhirong Yao,
- Zhirong Yao,
- Zhirong Yao,
- Zhirong Yao
Affiliations
- Zhe Sun
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhe Sun
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhe Sun
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhe Sun
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruoqu Wei
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruoqu Wei
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruoqu Wei
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruoqu Wei
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Chaolan Pan
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Chaolan Pan
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Chaolan Pan
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Chaolan Pan
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Cheng Ni
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Cheng Ni
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Cheng Ni
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Cheng Ni
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xue Zhang
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xue Zhang
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xue Zhang
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xue Zhang
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Wenbin Guan
- Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruhong Cheng
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruhong Cheng
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruhong Cheng
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ruhong Cheng
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Yan Gu
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Yan Gu
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Yan Gu
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Yan Gu
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Hong Yu
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Hong Yu
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Hong Yu
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Hong Yu
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Kejun He
- Department of Pediatric Hematology and Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhen Zhang
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhen Zhang
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhen Zhang
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhen Zhang
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xia Yu
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xia Yu
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xia Yu
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xia Yu
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhirong Yao
- Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhirong Yao
- Department of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhirong Yao
- Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China
- Zhirong Yao
- Department of Allergy, Dermatology Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1414573
- Journal volume & issue
-
Vol. 15
Abstract
Dedicator of cytokinesis 8 (DOCK8) deficiency represents a primary immunodeficiency with a wide range of clinical symptoms, including recurrent infections, atopy, and increased malignancy risk. This study presents a case of a 6-year-old girl with DOCK8 deficiency, characterized by severe, treatment-resistant herpetic infections who was successfully treated with siltuximab and glucocorticoids. The successful use of siltuximab in achieving remission highlights the pivotal role of interleukin-6 (IL-6) in DOCK8 deficiency pathogenesis and suggests that IL-6 modulation can be critical in managing DOCK8 deficiency-related viral infections, which may inform future therapeutic strategies for DOCK8 deficiency and similar immunodeficiencies.
Keywords
