Nature Communications (Feb 2023)

Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1

  • Philipp A. M. Schmidpeter,
  • John T. Petroff,
  • Leila Khajoueinejad,
  • Aboubacar Wague,
  • Cheryl Frankfater,
  • Wayland W. L. Cheng,
  • Crina M. Nimigean,
  • Paul M. Riegelhaupt

DOI
https://doi.org/10.1038/s41467-023-36765-w
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 14

Abstract

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Tandem pore (K2P) potassium channels set the cellular resting membrane potential in tissues throughout the body. Here, authors show how the composition of phospholipid within the bilayer may directly alter gating in this family of ion channels.