Communications Biology (Apr 2023)
Sub-millisecond conformational dynamics of the A2A adenosine receptor revealed by single-molecule FRET
- Ivan Maslov,
- Oleksandr Volkov,
- Polina Khorn,
- Philipp Orekhov,
- Anastasiia Gusach,
- Pavel Kuzmichev,
- Andrey Gerasimov,
- Aleksandra Luginina,
- Quinten Coucke,
- Andrey Bogorodskiy,
- Valentin Gordeliy,
- Simon Wanninger,
- Anders Barth,
- Alexey Mishin,
- Johan Hofkens,
- Vadim Cherezov,
- Thomas Gensch,
- Jelle Hendrix,
- Valentin Borshchevskiy
Affiliations
- Ivan Maslov
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Oleksandr Volkov
- Polina Khorn
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Philipp Orekhov
- Faculty of Biology, Shenzhen MSU-BIT University
- Anastasiia Gusach
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Pavel Kuzmichev
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Andrey Gerasimov
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Aleksandra Luginina
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Quinten Coucke
- Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry
- Andrey Bogorodskiy
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Valentin Gordeliy
- Institut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes–CEA–CNRS
- Simon Wanninger
- Physical Chemistry, Department of Chemistry, Center for Nano Science (CENS), Center for Integrated Protein Science (CIPSM) and Nanosystems Initiative München (NIM), Ludwig-Maximilians-Universität Munich
- Anders Barth
- Physical Chemistry, Department of Chemistry, Center for Nano Science (CENS), Center for Integrated Protein Science (CIPSM) and Nanosystems Initiative München (NIM), Ludwig-Maximilians-Universität Munich
- Alexey Mishin
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- Johan Hofkens
- Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry
- Vadim Cherezov
- Bridge Institute, Department of Chemistry, University of Southern California
- Thomas Gensch
- Laboratory for Photochemistry and Spectroscopy, Division for Molecular Imaging and Photonics, Department of Chemistry
- Jelle Hendrix
- Dynamic Bioimaging Lab, Advanced Optical Microscopy Centre, Biomedical Research Institute, Agoralaan C (BIOMED), Hasselt University
- Valentin Borshchevskiy
- Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology
- DOI
- https://doi.org/10.1038/s42003-023-04727-z
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 15
Abstract
Single-molecule FRET experiments with human A2A adenosine receptor in its apo and agonist-bound states in lipid nanodiscs provide insights into its conformational dynamics and activation.
