High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS

Andrew L. Hook; John Hogwood; Elaine Gray; Barbara Mulloy; Catherine L. R. Merry

doi:10.1038/s42004-021-00506-1

Communications Chemistry (May 2021)

High sensitivity analysis of nanogram quantities of glycosaminoglycans using ToF-SIMS

Andrew L. Hook,
John Hogwood,
Elaine Gray,
Barbara Mulloy,
Catherine L. R. Merry

Affiliations

Andrew L. Hook: Advanced Materials and Healthcare Technology, University of Nottingham
John Hogwood: National Institute for Biological Standards and Control
Elaine Gray: National Institute for Biological Standards and Control
Barbara Mulloy: Institute for Pharmaceutical Science, King’s College London
Catherine L. R. Merry: Stem Cell Glycobiology Group, Biodiscovery Institute, Faculty of Medicine and Health Sciences, University of Nottingham

DOI: https://doi.org/10.1038/s42004-021-00506-1
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 8

Abstract

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Glycosaminoglycans are an important class of carbohydrates, but pose substantial analytical challenges. Here ToF-SIMS combined with multivariate analysis distinguishes six classes of glycosaminoglycans, including distinguishing heparin samples from different animal sources at a sensitivity as low as 0.001 wt%

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

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