Nature Communications (Mar 2017)
Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
- Xusheng Wang,
- Haiyan Chen,
- Ruiyun Tian,
- Yiling Zhang,
- Marina S. Drutskaya,
- Chengmei Wang,
- Jianfeng Ge,
- Zhimeng Fan,
- Deqiang Kong,
- Xiaoxiao Wang,
- Ting Cai,
- Ying Zhou,
- Jingwen Wang,
- Jinmei Wang,
- Shan Wang,
- Zhihai Qin,
- Huanhuan Jia,
- Yue Wu,
- Jia Liu,
- Sergei A. Nedospasov,
- Edward E. Tredget,
- Mei Lin,
- Jianjun Liu,
- Yuyang Jiang,
- Yaojiong Wu
Affiliations
- Xusheng Wang
- School of Life Sciences, Tsinghua University
- Haiyan Chen
- The Shenzhen Key Laboratory of Health Sciences and Technology
- Ruiyun Tian
- The Shenzhen Key Laboratory of Health Sciences and Technology
- Yiling Zhang
- Department of Orthopedics, The General Hospital of Chinese People's Liberation Army
- Marina S. Drutskaya
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Chengmei Wang
- School of Life Sciences, Tsinghua University
- Jianfeng Ge
- School of Life Sciences, Tsinghua University
- Zhimeng Fan
- School of Life Sciences, Tsinghua University
- Deqiang Kong
- School of Life Sciences, Tsinghua University
- Xiaoxiao Wang
- School of Life Sciences, Tsinghua University
- Ting Cai
- School of Life Sciences, Tsinghua University
- Ying Zhou
- School of Life Sciences, Tsinghua University
- Jingwen Wang
- School of Life Sciences, Tsinghua University
- Jinmei Wang
- School of Life Sciences, Tsinghua University
- Shan Wang
- School of Life Sciences, Tsinghua University
- Zhihai Qin
- Institute of Biophysics, Chinese Academy of Sciences
- Huanhuan Jia
- Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals
- Yue Wu
- Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals
- Jia Liu
- College of Life Sciences, Northeast Forestry University
- Sergei A. Nedospasov
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Edward E. Tredget
- Department of Surgery, Wound Healing Research Group, University of Alberta
- Mei Lin
- The Shenzhen Key Laboratory of Health Sciences and Technology
- Jianjun Liu
- Medical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention
- Yuyang Jiang
- State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University
- Yaojiong Wu
- The Shenzhen Key Laboratory of Health Sciences and Technology
- DOI
- https://doi.org/10.1038/ncomms14091
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Hair can be regenerated after skin wounding. Here the authors show that inflammatory macrophages produce TNF that activates Wnt signalling in hair follicle stem cells to drive this hair regeneration after wound repair in mice.
