Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

Sadhan Das; Parijat Senapati; Zhuo Chen; Marpadga A. Reddy; Rituparna Ganguly; Linda Lanting; Varun Mandi; Anita Bansal; Amy Leung; Selena Zhang; Ye Jia; Xiwei Wu; Dustin E. Schones; Rama Natarajan

doi:10.1038/s41467-017-01629-7

Nature Communications (Nov 2017)

Regulation of angiotensin II actions by enhancers and super-enhancers in vascular smooth muscle cells

Sadhan Das,
Parijat Senapati,
Zhuo Chen,
Marpadga A. Reddy,
Rituparna Ganguly,
Linda Lanting,
Varun Mandi,
Anita Bansal,
Amy Leung,
Selena Zhang,
Ye Jia,
Xiwei Wu,
Dustin E. Schones,
Rama Natarajan

Affiliations

Sadhan Das: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Parijat Senapati: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Zhuo Chen: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Marpadga A. Reddy: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Rituparna Ganguly: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Linda Lanting: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Varun Mandi: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Anita Bansal: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Amy Leung: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Selena Zhang: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Ye Jia: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Xiwei Wu: Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope
Dustin E. Schones: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope
Rama Natarajan: Department of Diabetes Complications and Metabolism, Diabetes Metabolism Research Institute, Beckman Research Institute of City of Hope

DOI: https://doi.org/10.1038/s41467-017-01629-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 19

Abstract

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The repertoire of tissue-specific distal regulators of gene transcription enhancers defines homeostasis or disease. Here, the authors reveal the enhancer and super-enhancer signature of vascular smooth muscle cells under normal and angiotensin II stimuli, providing new insight into the transcriptional regulation of vascular pathologies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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