The clinical outcomes of gut-brain axis (GBA) microbiota influence on psychiatric disordersThe clinical outcomes of gut-brain axis (GBA) microbiota influence on psychiatric disorders

Abstract

The gut microbiome plays an important role in the health of the body. The study of its effect on mental problems has become the main topic of this study. As a matter of fact, every change in the gut microbiota composition can influence on mood and anxiety and vice versa. So, considering this “microbiota-gut-brain” axis (GBA) is so important. In this narrative review, the most recent reproduced information on GBA roles in neuropsychiatric disorders, and clinical significance have been considered. The gut microbial population is formed from birth and transforms from an immature state to the postnatal period into a more intricate and diverse adult ecosystem. In this review, we had some findings that GBA implicated in some psychiatric problems which can be a dysregulation consequence. In addition, some bacteria have been implicated in causing mental disorders in humans such as depression, obsessive-compulsive disorder, psychiatric disorders, stress disorders, schizophrenia and, autism. The absence of balance in GBA natural state can cause several negative consequences on host health which leads to neurological problems. Possibly, findings were delineating an interesting new etiological pathway for future exploration.

Keywords

• Gut-brain axis (GBA);
• Microbiota;
• Obsessive-compulsive disorder;
• Psychiatric disorders;
• Stress-related disorders;
• Schizophrenia;