Requirements for human mesenchymal stem cell‐derived small extracellular vesicles

Qing Li; Bo Li; Teng Ye; Wenrong Xu; Hang Yin; Zhifeng Deng; Haiyan Li; Xiaomei Yan; Xiaoke Hao; Li Li; Zhihua Tao; Bicheng Liu; Zhengsheng Chen; Lei Luo; Hui Qian; Qing‐Ling Fu; Qian Wang; Lei Zheng; Yang Wang

doi:10.1002/INMD.20220015

Interdisciplinary Medicine (Jan 2023)

Requirements for human mesenchymal stem cell‐derived small extracellular vesicles

Qing Li,
Bo Li,
Teng Ye,
Wenrong Xu,
Hang Yin,
Zhifeng Deng,
Haiyan Li,
Xiaomei Yan,
Xiaoke Hao,
Li Li,
Zhihua Tao,
Bicheng Liu,
Zhengsheng Chen,
Lei Luo,
Hui Qian,
Qing‐Ling Fu,
Qian Wang,
Lei Zheng,
Yang Wang

Affiliations

Qing Li: Institute of Microsurgery on Extremities Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Bo Li: Department of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou China
Teng Ye: Institute of Microsurgery on Extremities Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Wenrong Xu: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine Department of laboratory Medicine School of Medicine Jiangsu University Zhenjiang Jiangsu China
Hang Yin: School of Pharmaceutical Sciences Beijing Frontier Research Center for Biological Structure Tsinghua‐Peking Center for Life Sciences Tsinghua University Beijing China
Zhifeng Deng: Department of Neurosurgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Haiyan Li: Chemical and Environmental Engineering School of Engineering STEM College RMIT University Melbourne Victoria Australia
Xiaomei Yan: Department of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University Fujian China
Xiaoke Hao: Xijing Hospital Air Force Medical University Xi'an Shaanxi China
Li Li: Department of Laboratory Medicine Shanghai General Hospital Shanghai JiaoTong University School of Medicine Shanghai China
Zhihua Tao: The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China
Bicheng Liu: Institute of Nephrology Zhong Da Hospital Southeast University School of Medicine Nanjing China
Zhengsheng Chen: Institute of Microsurgery on Extremities Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
Lei Luo: School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China
Hui Qian: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine Department of laboratory Medicine School of Medicine Jiangsu University Zhenjiang Jiangsu China
Qing‐Ling Fu: Otorhinolaryngology Hospital The First Affiliated Hospital Sun Yat‐sen University Guangzhou China
Qian Wang: Laboratory of Medicine Center Zhujiang Hospital Southern Medical University Guangzhou Guangdong China
Lei Zheng: Department of Laboratory Medicine Nanfang Hospital Southern Medical University Guangzhou China
Yang Wang: Institute of Microsurgery on Extremities Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China

DOI: https://doi.org/10.1002/INMD.20220015
Journal volume & issue: Vol. 1, no. 1
pp. n/a – n/a

Abstract

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Abstract “Requirements for human mesenchymal stem cell‐derived small extracellular vesicles” is the first set of guidelines on human mesenchymal stem cell‐derived small extracellular vesicles (hMSC‐sEVs) in China, jointly drafted and agreed upon by experts from the Chinese Society for Extracellular Vesicles. It was released by the Chinese Research Hospital Association on 28 December 2021 and came into effect on 1 January 2022. This standard specifies the technical requirements, test methods and regulations, packaging, instructions for use, labeling, storage, transportation, and waste handling for hMSC‐sEVs, which apply to the production and quality control of hMSC‐sEVs. We hope that the publication of these guidelines will promote consensus on the research and application of human mesenchymal stem cell‐derived small extracellular vesicles and accelerate its international standardization.

Published in Interdisciplinary Medicine

ISSN: 2832-6237 (Print); 2832-6245 (Online)
Publisher: Wiley-VCH
Country of publisher: Germany
LCC subjects: Medicine: Medicine (General): Medical technology; Technology: Chemical technology: Biotechnology
Website: https://onlinelibrary.wiley.com/journal/28326245

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