Nature Communications (Mar 2019)
A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes
- Naofumi Asano,
- Juntaro Matsuzaki,
- Makiko Ichikawa,
- Junpei Kawauchi,
- Satoko Takizawa,
- Yoshiaki Aoki,
- Hiromi Sakamoto,
- Akihiko Yoshida,
- Eisuke Kobayashi,
- Yoshikazu Tanzawa,
- Robert Nakayama,
- Hideo Morioka,
- Morio Matsumoto,
- Masaya Nakamura,
- Tadashi Kondo,
- Ken Kato,
- Naoto Tsuchiya,
- Akira Kawai,
- Takahiro Ochiya
Affiliations
- Naofumi Asano
- Division of Rare Cancer Research, National Cancer Center Research Institute
- Juntaro Matsuzaki
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
- Makiko Ichikawa
- Toray Industries
- Junpei Kawauchi
- Toray Industries
- Satoko Takizawa
- Toray Industries
- Yoshiaki Aoki
- Dynacom Co., Ltd.
- Hiromi Sakamoto
- Division of Biobank and Tissue Resources, National Cancer Center Research Institute
- Akihiko Yoshida
- Department of Pathology and Clinical Laboratory, National Cancer Center Hospital
- Eisuke Kobayashi
- Department of Musculoskeletal Oncology, National Cancer Center Hospital
- Yoshikazu Tanzawa
- Department of Musculoskeletal Oncology, National Cancer Center Hospital
- Robert Nakayama
- Department of Orthopaedic Surgery, Keio University School of Medicine
- Hideo Morioka
- Department of Orthopaedic Surgery, Keio University School of Medicine
- Morio Matsumoto
- Department of Orthopaedic Surgery, Keio University School of Medicine
- Masaya Nakamura
- Department of Orthopaedic Surgery, Keio University School of Medicine
- Tadashi Kondo
- Division of Rare Cancer Research, National Cancer Center Research Institute
- Ken Kato
- Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital
- Naoto Tsuchiya
- Laboratory of Molecular Carcinogenesis, National Cancer Center Research Institute
- Akira Kawai
- Department of Musculoskeletal Oncology, National Cancer Center Hospital
- Takahiro Ochiya
- Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
- DOI
- https://doi.org/10.1038/s41467-019-09143-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
Sarcomas are rare malignant tumours of bone and soft tissue whose diagnosis remain difficult. Here, the authors analyse serum samples from over 1000 patients and using separate discovery, training and validation cohorts, identify and validate a 7-microRNA index that distinguishes malignant sarcomas from benign disease.
