RESULTS OF PRECLINICAL SAFETY TESTING COMPARISON FOR IBUPROFEN DRUG PRODUCTS

Abstract

The article contains materials, methods and results of preclinical experimental test of acute toxicity of drugs «Ibuprofen», suspension for oral administration [for children], LP 001651 from 13.04.2012 and referent «Nurofen for children», suspension for oral administration, P N014745/01 from 22.08.2008. Ibuprofen preparations compared were found equivalent in acute toxicity studies. The work will be continued in order to prove the bioequivalence of the claimed preparations.

Keywords

• ibuprofen
• safety
• acute toxicity
• rats
• preclinical tests