Journal of Hematology & Oncology (Nov 2019)
Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study
- Alice Ramassone,
- Andrea D’Argenio,
- Angelo Veronese,
- Alessio Basti,
- Shimaa Hassan AbdelAziz Soliman,
- Stefano Volinia,
- Cristian Bassi,
- Sara Pagotto,
- Manuela Ferracin,
- Laura Lupini,
- Elena Saccenti,
- Veronica Balatti,
- Felice Pepe,
- Laura Z. Rassenti,
- Idanna Innocenti,
- Francesco Autore,
- Laura Marzetti,
- Renato Mariani-Costantini,
- Thomas J. Kipps,
- Massimo Negrini,
- Luca Laurenti,
- Rosa Visone
Affiliations
- Alice Ramassone
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Andrea D’Argenio
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Angelo Veronese
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Alessio Basti
- Department of Neuroscience, Imaging and Clinical Sciences, University G. d’Annunzio Chieti-Pescara
- Shimaa Hassan AbdelAziz Soliman
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Stefano Volinia
- Department of Morphology, Surgery and Experimental Medicine, University of Ferrara
- Cristian Bassi
- Department of Morphology, Surgery and Experimental Medicine, University of Ferrara
- Sara Pagotto
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Manuela Ferracin
- Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna
- Laura Lupini
- Department of Morphology, Surgery and Experimental Medicine, University of Ferrara
- Elena Saccenti
- Department of Morphology, Surgery and Experimental Medicine, University of Ferrara
- Veronica Balatti
- Department of Cancer Biology and Genetics and Comprehensive Cancer Center at the Wexner Medical Center, The Ohio State University
- Felice Pepe
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Laura Z. Rassenti
- Department of Medicine, Moores Cancer Center, University of California at San Diego
- Idanna Innocenti
- Fondazione Policlinico Universitario A Gemelli IRCCS
- Francesco Autore
- Fondazione Policlinico Universitario A Gemelli IRCCS
- Laura Marzetti
- Department of Neuroscience, Imaging and Clinical Sciences, University G. d’Annunzio Chieti-Pescara
- Renato Mariani-Costantini
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- Thomas J. Kipps
- Department of Medicine, Moores Cancer Center, University of California at San Diego
- Massimo Negrini
- Department of Morphology, Surgery and Experimental Medicine, University of Ferrara
- Luca Laurenti
- Fondazione Policlinico Universitario A Gemelli IRCCS
- Rosa Visone
- Unit of General Pathology, Center for Advanced Studies and Technology (CAST), University G. d’Annunzio Chieti-Pescara
- DOI
- https://doi.org/10.1186/s13045-019-0802-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 5
Abstract
Abstract Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the selection and expansion of CLL clone(s) precede an aggressive disease shift. We found that clonal evolution occurs in all CLL patients, irrespective of the clinical outcome, but is faster during disease progression. In particular, changes in the frequency of nucleotide variants (NVs) in specific CLL-related genes may represent an indicator of poor clinical outcome.
Keywords
