Nature Communications (Aug 2020)

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

  • Christopher Bruhn,
  • Arta Ajazi,
  • Elisa Ferrari,
  • Michael Charles Lanz,
  • Renaud Batrin,
  • Ramveer Choudhary,
  • Adhish Walvekar,
  • Sunil Laxman,
  • Maria Pia Longhese,
  • Emmanuelle Fabre,
  • Marcus Bustamente Smolka,
  • Marco Foiani

DOI
https://doi.org/10.1038/s41467-020-17961-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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The relationship between DNA damage response (DDR) and regulation of the tolerance to glucose restriction is currently unclear. Here the authors reveal that maintaining a physiological level of histones by Rad53-Spt21 is necessary for glucose tolerance via multiple parallel pathways, including derepression of subtelomeric genes and acetyl-coA regulation by histone acetylation.