Lewis acid-promoted direct synthesis of isoxazole derivatives

Abstract

Isoxazole derivatives were synthesized via a one-pot method utilizing 2-methylquinoline derivatives as template substrates, sodium nitrite as a nitrogen-oxygen source, and solely using aluminum trichloride as the additive. This approach circumvents the need for costly or highly toxic transition metals and presents a novel pathway for the synthesis of isoxazole derivatives.

Keywords

• aluminum trichloride
• lewis acid
• isoxazole derivatives
• sodium nitrite
• transition metals