Bulletin of the Chemical Society of Ethiopia (Jul 2017)
Synthesis and anti-inflammatory evaluation of novel thiadiazol derivatives of Mefenamic acid
Abstract
In the search for new potential non-steroidal anti-inflammatory agents, some novel Mefenamic acid derivatives were synthesized and confirmed by spectroscopic data. The anti-inflammatory activities of these compounds were evaluated by the croton oil-induced ear oedema test in mice. The preliminary pharmacological evaluations indicate that these new compounds showed potent anti-inflammatory activities compare to control and Indomethacin groups.
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