SERUM ANTIBODI-IMUNOGLOBULIN-G-SUBKLAS SPESIFIK TERHADAP NON-LEUKOTOKSIK ACTINOBACILLUS ACTINOMYCETEMCOMITANS

Abstract

Serum specific IgG subclass antibodies to non-leukotoxic strains of Actinobacillus actinomycetemcomitans (Aa) NCTC 9710 and NCTC 10979 were quantified by radioimmunoassay. Samples were taken from sera of 10 patients with Juvenile Periodontitis (JP) and 10 from healthy periodontal individuals as control. The results show that JP patients had higher IgG2 antibody levels to Aa NCTC 9710 (ABT50 = 620) than the other IgG subclasses (IgG1 = 300, IgG3 = 370, and IgG4= 500). The JP patients had also higher IgG2 antibody levels to Aa. NCTC 10979 (600) when compared with the other IgG subclasses (IgG1 = 300, IgG3 = 500, and IgG4= 400). Whilst, the control gorup had lower IgG subclass antibody level as compared with the JP group. In conclusion, the JP patients had an elevation of IgG2 subclass antibodies to non-leukotoxic Actinobacillus actinomycetemcomitans.