Nature Communications (Oct 2022)
Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection
- Olivier Reynard,
- Claudia Gonzalez,
- Claire Dumont,
- Mathieu Iampietro,
- Marion Ferren,
- Sandrine Le Guellec,
- Lajoie Laurie,
- Cyrille Mathieu,
- Gabrielle Carpentier,
- Georges Roseau,
- Francesca T. Bovier,
- Yun Zhu,
- Deborah Le Pennec,
- Jérome Montharu,
- Amin Addetia,
- Alexander L. Greninger,
- Christopher A. Alabi,
- Elise Brisebard,
- Anne Moscona,
- Laurent Vecellio,
- Matteo Porotto,
- Branka Horvat
Affiliations
- Olivier Reynard
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- Claudia Gonzalez
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- Claire Dumont
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- Mathieu Iampietro
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- Marion Ferren
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- Sandrine Le Guellec
- DTF-Aerodrug, R&D aerosolltherapy department of DTF medical (Saint Etienne, France), Faculté de médecine, Université de Tours
- Lajoie Laurie
- Université de Tours, Institut national de recherche pour l’agriculture, l’alimentation et l’environnement (INRAe), UMR1282, Infectiologie et santé publique (ISP)
- Cyrille Mathieu
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- Gabrielle Carpentier
- PST-A, Université de Tours
- Georges Roseau
- PST-A, Université de Tours
- Francesca T. Bovier
- Center for Host-Pathogen Interaction, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons
- Yun Zhu
- Center for Host-Pathogen Interaction, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons
- Deborah Le Pennec
- INSERM, Research Center for Respiratory Diseases, CEPR U1100, Université de Tours
- Jérome Montharu
- PST-A, Université de Tours
- Amin Addetia
- Department of Laboratory Medicine and Pathology, University of Washington Medical Center
- Alexander L. Greninger
- Department of Laboratory Medicine and Pathology, University of Washington Medical Center
- Christopher A. Alabi
- Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University
- Elise Brisebard
- UMR703, PAnTher APEX, INRAE/Oniris
- Anne Moscona
- Center for Host-Pathogen Interaction, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons
- Laurent Vecellio
- PST-A, Université de Tours
- Matteo Porotto
- Center for Host-Pathogen Interaction, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons
- Branka Horvat
- CIRI, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS, UMR5308, Univ Lyon, Université Claude Bernard Lyon 1, École Normale Supérieure de Lyon
- DOI
- https://doi.org/10.1038/s41467-022-33832-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Despite the availability of a safe and effective vaccine, measles remains the leading cause of child death among vaccine-preventable diseases. In this work, authors utilised a cynomolgus macaque model of infection, and a mesh nebuliser administration approach, to show efficacy of their aerosolized lipopeptide fusion inhibitor against the measles virus.
