Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor

Tongde Wu; Julianne Huang; Patrick J. Moore; Michael S. Little; William G. Walton; Robert C. Fellner; Neil E. Alexis; Y. Peter Di; Matthew R. Redinbo; Stephen L. Tilley; Robert Tarran

doi:10.1038/ncomms14118

Nature Communications (Feb 2017)

Identification of BPIFA1/SPLUNC1 as an epithelium-derived smooth muscle relaxing factor

Tongde Wu,
Julianne Huang,
Patrick J. Moore,
Michael S. Little,
William G. Walton,
Robert C. Fellner,
Neil E. Alexis,
Y. Peter Di,
Matthew R. Redinbo,
Stephen L. Tilley,
Robert Tarran

Affiliations

Tongde Wu: Cystic Fibrosis Center/Marsico Lung Institute
Julianne Huang: Cystic Fibrosis Center/Marsico Lung Institute
Patrick J. Moore: Cystic Fibrosis Center/Marsico Lung Institute
Michael S. Little: Department of Chemistry, Genome Science Building
William G. Walton: Department of Chemistry, Genome Science Building
Robert C. Fellner: Cystic Fibrosis Center/Marsico Lung Institute
Neil E. Alexis: Center for Environmental Medicine, Asthma, and Lung Biology, US EPA Human Studies Facility
Y. Peter Di: Department of Environmental and Occupational Health, University of Pittsburgh
Matthew R. Redinbo: Department of Chemistry, Genome Science Building
Stephen L. Tilley: Cystic Fibrosis Center/Marsico Lung Institute
Robert Tarran: Cystic Fibrosis Center/Marsico Lung Institute

DOI: https://doi.org/10.1038/ncomms14118
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Asthma is characterized by abnormal airway hyperresponsiveness. Here the authors identify BPIFA1 as a factor secreted by airway epithelial cells, and show that it regulates contractility of airway smooth muscle cells by binding to and regulating the Orai1 Ca2+channel.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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