Xin yixue (Mar 2022)

Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma

  • Zhang Fan, Zhang Guoxu, Liu Xiuting, Wang Jigang, Liu Yanqin, Tong Danjiang, Liu Jinghua, Zhou Fan

DOI
https://doi.org/10.3969/j.issn.0253-9802.2022.03.010
Journal volume & issue
Vol. 53, no. 3
pp. 199 – 203

Abstract

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Objective To investigate the significance of metabolic parameters and biochemical indexes of 18F-FDG-PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma （DLBCL）. Methods Clinical data of 194 patients with DLBCL were analyzed retrospectively. The mid-term evaluation results were recorded. The proportion of patients who achieved complete remission （CR） was statistically compared among different clinical indexes（β2-microglobulin （β2-MG）, dual expression, triple expression, Ann Arbor stage, international prognostic index （IPI） and Deauville 5-point scale （D5PS） score） and metabolic parameters of 18F-FDG-PET/CT （the maximum standardized uptake value （SUVmax）, the sum of the maximum standardized uptake value （SUVmaxsum）, the mean standardized uptake value （SUVmean） and the maximum decrease range of SUV （△SUVmax））. The influence of metabolic parameters and biochemical indexes of18F-FDG-PET/CT on the 2-year progression-free survival （PFS） was evaluated by Cox regression models and Kaplan-Meier survival analysis. The correlation between SUVmax and β2-MG, Ann Arbor stage and IPI score was analyzed. Results The proportion of patients with β2-MG > 2.3 mg/L, Ann Arbor stage Ⅲ/Ⅳ, IPI score > 2, SUVmax > 17.00 and SUVmaxsum > 38.60 who achieved CR was significantly decreased, the △SUVmax of patients achieving CR was significantly higher than that of those without CR（all P < 0.05）. Univariate Cox regression analysis showed that β2-MG, Ann Arbor stage, IPI score, dual expression, triple expression, SUVmaxsum and D5PS socre were significantly correlated with the 2-year PFS of DLBCL patients （all P < 0.05）. Multivariate analysis showed that Ann Arbor stage Ⅲ/Ⅳ （HR = 4.486, P = 0.001） was an independent risk factor for the 2-year PFS, and D5PS score of 1-3 （HR = 0.256, P < 0.001） was an independent protective factor for the 2-year PFS of patients with DLBCL. Spearman’s rank correlation analysis demonstrated that SUVmax was significantly associated with β2-MG （rs = 0.348, P = 0.001）, Ann Arbor stage （rs = 0.236, P = 0.022） and IPI score （rs = 0.305, P = 0.003）. Conclusions The metabolic parameters of18F-FDG-PET/CT are associated with clinical indexes. Ann Arbor stage and D5PS can be utilized as reference indexes for clinical prognosis of DLBCL patients.

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