Communications Biology (Jul 2021)
FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression
- Kia Joo Puan,
- Boris San Luis,
- Nurhashikin Yusof,
- Dilip Kumar,
- Anand Kumar Andiappan,
- Wendy Lee,
- Samanta Cajic,
- Dragana Vuckovic,
- Jing De Chan,
- Tobias Döllner,
- Han Wei Hou,
- Yunxuan Jiang,
- Chao Tian,
- the 23andMe Research Team,
- Erdmann Rapp,
- Michael Poidinger,
- De Yun Wang,
- Nicole Soranzo,
- Bernett Lee,
- Olaf Rötzschke
Affiliations
- Kia Joo Puan
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Boris San Luis
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Nurhashikin Yusof
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Dilip Kumar
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Anand Kumar Andiappan
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Wendy Lee
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Samanta Cajic
- Max Planck Institute for Dynamics of Complex Technical Systems
- Dragana Vuckovic
- Department of Human Genetics, Wellcome Sanger Institute
- Jing De Chan
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Tobias Döllner
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Han Wei Hou
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Yunxuan Jiang
- 23andMe, Inc.
- Chao Tian
- 23andMe, Inc.
- the 23andMe Research Team
- Erdmann Rapp
- Max Planck Institute for Dynamics of Complex Technical Systems
- Michael Poidinger
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- De Yun Wang
- Department of Otolaryngology, National University of Singapore
- Nicole Soranzo
- Department of Human Genetics, Wellcome Sanger Institute
- Bernett Lee
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- Olaf Rötzschke
- Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research)
- DOI
- https://doi.org/10.1038/s42003-021-02295-8
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Puan and San Luis et al. find that FUT6, encoding a fucosyltransferase, is required for the “rolling” behavior of certain white blood cells that enables them to move from blood vessels to tissues. They show that FUT6 deficiency leads to a loss of the tetrasaccharide sLex on the surface of basophils, resulting in cells that are less sticky and therefore less able to form the necessary adhesions for exiting the blood vessel to drive the allergic reaction.
