Diagnostic Accuracy of IL-17A/IL-17F Gene Polymorphism and Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis: Meta-analysis Study (2014-2020)

Abstract

Background: The anti-CarP antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis. Also, the associations between Interleukin-17A and17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. Objectives: to evaluate the diagnostic value of the anti-CarP antibody for RA and to determine the relation between IL-17F and IL-17A gene polymorphism with rheumatoid arthritis. Methods: A literature review of PubMed, PsycINFO, BioMed Central and Medline databases was carried out to identify peer reviewed peer reviewed studies, published between 2014 and 2020. Results: Fifteen studies were included in total and the pooled sensitivity, specificity, and positive and negative likelihood ratios for anti-CarP antibody were 42% (95% CI, 38% to 45%), 96% (95% CI, 95% to 97%), 10.2 (95% CI, 7.5 to 13.9), and 0.61 (95% CI, 0.57 to 0.65), respectively. The synopsis diagnostic odds ratio was 17 (95% CI, 12 to 24), and the area under summary receiver operator characteristic curve was 80% (95% CI, 77% to 84%). Further, there were significant associations between IL-17rs2275913 G allele with OA, RA susceptibility (P < 0.05) but not AS. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < 0.05). Conclusion: The moderate value of Anti-CarP antibody in the diagnosis of RA is relatively low sensitivity and high specificity. As well, IL-17F gene rs763780 C allele confers the increasing in possibility of inflammatory arthritis.

Keywords

• accuracy; il-17a/il-17f; anti-carp antibody; gene polymorphism; rheumatoid arthritis; meta-analysis study