INVESTIGATION OF THE EFFECTIVENESS OF MAGNESIUM SULFATE USE IN THE COMPOSITION OF FLUID RESUSCITATION FOR THE PREVENTION OF CELLULAR MEMBRANE DAMAGE IN PATIENTS SUFFERING FROM POLYTRAUMA UNDER CONDITIONS OF HYPOVOLEMIC TRAUMATIC SHOCK AND ISCHEMIA

Abstract

In 24 patients in the state of traumatic shock, against the background of polytrauma, the effectiveness of anti-shock fluid resuscitation at an early hospital stage studied. A comparative study of the effect of intensive care, recommended by the Protocols of the Ministry of Health of Ukraine, and adding to its composition hypertonic solution of magnesium sulfate in a normal saline conducted. The use of magnesium sulfate is justified by accelerating the recovery of circulating blood volume with the simultaneous elimination of tachycardia and the improvement of cardiac contraction mechanics, as well as the limitation of cell membrane damage by limiting ionized calcium ingestion to them, followed by a decrease in the intensity of free radical oxidation processes. Two groups of study created for 12 patients in each group: the main use of infusion of magnesium sulfate and control with a «standard» resuscitation. Changes in the parameters of central and peripheral hemodynamics at the stages of rendering assistance, carboxylated hemoglobin and malonic dialdehyde in the blood studied. It discovered that the use of magnesium sulfate as a fluid resuscitation facilitated a significant acceleration of the improvement of the central and peripheral hemodynamics, as well as the reduction of carboxylated hemoglobin and malonic dialdehyde production in the body during the first 24 hours after the surgical operation.

Keywords

• traumatic shock
• ischemia / reperfusion
• fluid resuscitation
• hemodynamics
• free radical damage
• magnesium sulfate
• carbon monoxide
• malonic dialdehyde.