Frontiers in Genetics (Sep 2022)
Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature
- Chuling Hu,
- Chuling Hu,
- Chuling Hu,
- Du Cai,
- Du Cai,
- Du Cai,
- Min-Er Zhong,
- Min-Er Zhong,
- Min-Er Zhong,
- Dejun Fan,
- Dejun Fan,
- Dejun Fan,
- Dejun Fan,
- Cheng-Hang Li,
- Cheng-Hang Li,
- Cheng-Hang Li,
- Min-Yi Lv,
- Min-Yi Lv,
- Min-Yi Lv,
- Ze-Ping Huang,
- Ze-Ping Huang,
- Ze-Ping Huang,
- Wei Wang,
- Xiao-Jian Wu,
- Xiao-Jian Wu,
- Xiao-Jian Wu,
- Feng Gao,
- Feng Gao,
- Feng Gao
Affiliations
- Chuling Hu
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Chuling Hu
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Chuling Hu
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Du Cai
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Du Cai
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Du Cai
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Min-Er Zhong
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Min-Er Zhong
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Min-Er Zhong
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Dejun Fan
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Dejun Fan
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Dejun Fan
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Dejun Fan
- Department of Gastrointestinal Endoscopy, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Cheng-Hang Li
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Cheng-Hang Li
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Cheng-Hang Li
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Min-Yi Lv
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Min-Yi Lv
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Min-Yi Lv
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Ze-Ping Huang
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Ze-Ping Huang
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Ze-Ping Huang
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Wei Wang
- Department of Pathology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Xiao-Jian Wu
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Xiao-Jian Wu
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Xiao-Jian Wu
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Feng Gao
- Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- Feng Gao
- Guangdong Institute of Gastroenterology, Guangzhou, China
- Feng Gao
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fgene.2022.993714
- Journal volume & issue
-
Vol. 13
Abstract
Long non-coding RNAs (lncRNAs) remodel the tumor immune microenvironment (TIME) by regulating the functions of tumor-infiltrating immune cells. It remains uncertain the way that TIME-related lncRNAs (TRLs) influence the prognosis and immunotherapy response of colorectal cancer (CRC). Aiming at providing survival and immunotherapy response predictions, a CRC TIME-related lncRNA signature (TRLs signature) was developed and the related potential regulatory mechanisms were explored with a comprehensive analysis on gene expression profiles from 97 immune cell lines, 61 CRC cell lines and 1807 CRC patients. Stratifying CRC patients with the TRLs signature, prolonged survival was observed in the low-risk group, while the patients in the high-risk group had significantly higher pro-tumor immune cells infiltration and higher immunotherapy response rate. Through the complex TRLs-mRNA regulation network, immunoregulation pathways and immunotherapy response pathways were found to be differently activated between the groups. In conclusion, the CRC TRLs signature is capable of making prognosis and immunotherapy response predictions, which may find application in stratifying patients for immunotherapy in the bedside.
Keywords
- colorectal cancer
- tumor microenvironment
- tumor immune microenvironment
- long non-coding RNA
- immunotherapy
