CASE STUDY OF USING THE DOMESTIC ANALOGUE OF CYCLOSPORINE A

Abstract

The article illustrates results of an important trial for the Russian pharmaceutical industry, an assessment of the efficacy and safety of domestic immunosuppressive medication Cyclosporine A. A comparative analysis was made of pharmacokinetics, hepato-, myelo- and renal toxicity of domestic Cyclosporine A and Novartis-manufactured Cyclosporine A in patients with a renal allotransplant. The authors convincingly demonstrated the comparability by practically all studied parameters after a 2-week administration of the domestic analogue. Key words: Cyclosporine A, efficacy, safety, immunosuppression, kidney transplantation. (Pediatric Pharmacology. – 2010; 7(5):82-87)