Nature Communications (Jun 2022)

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery

  • Zhanna Alekseenko,
  • José M. Dias,
  • Andrew F. Adler,
  • Mariya Kozhevnikova,
  • Josina Anna van Lunteren,
  • Sara Nolbrant,
  • Ashwini Jeggari,
  • Svitlana Vasylovska,
  • Takashi Yoshitake,
  • Jan Kehr,
  • Marie Carlén,
  • Andrey Alexeyenko,
  • Malin Parmar,
  • Johan Ericson

DOI
https://doi.org/10.1038/s41467-022-30777-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Stem cell based replacement therapies could provide a treatment for Parkinson’s disease. Here the authors outline a retinoic acid-based approach for robust derivation of dopamine neurons from stem cells that restore motor deficits in parkinsonian rats.