Specific antibody deficiency and autoinflammatory disease extend the clinical and immunological spectrum of heterozygous NFKB1 loss-of-function mutations in humans

• Cyrill Schipp,
• Schafiq Nabhani,
• Kirsten Bienemann,
• Natalia Simanovsky,
• Shlomit Kfir-Erenfeld,
• Nathalie Assayag-Asherie,
• Prasad T. Oommen,
• Shoshana Revel-Vilk,
• Andrea Hönscheid,
• Michael Gombert,
• Sebastian Ginzel,
• Daniel Schäfer,
• Hans-Jürgen Laws,
• Eitan Yefenof,
• Bernhard Fleckenstein,
• Arndt Borkhardt,
• Polina Stepensky,
• Ute Fischer

Affiliations

Cyrill Schipp

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Schafiq Nabhani

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Kirsten Bienemann

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Natalia Simanovsky

Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel

Shlomit Kfir-Erenfeld

The Lautenberg Research Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Nathalie Assayag-Asherie

The Lautenberg Research Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Prasad T. Oommen

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Shoshana Revel-Vilk

Pediatric Hematology Oncology and Bone Marrow Transplantation Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel

Andrea Hönscheid

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Michael Gombert

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Sebastian Ginzel

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany;Department of Computer Science, Bonn-Rhine-Sieg University of Applied Sciences, Sankt Augustin, Germany

Daniel Schäfer

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Hans-Jürgen Laws

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Eitan Yefenof

The Lautenberg Research Center, Hebrew University-Hadassah Medical School, Jerusalem, Israel

Bernhard Fleckenstein

Department of Clinical and Molecular Virology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany

Arndt Borkhardt

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany

Polina Stepensky

Pediatric Hematology Oncology and Bone Marrow Transplantation Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel

Ute Fischer

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany