Nature Communications (Nov 2019)

In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls

  • Wei Jiang,
  • James R. Birtley,
  • Shu-Chen Hung,
  • Weiqi Wang,
  • Shin-Heng Chiou,
  • Claudia Macaubas,
  • Birgitte Kornum,
  • Lu Tian,
  • Huang Huang,
  • Lital Adler,
  • Grant Weaver,
  • Liying Lu,
  • Alexandra Ilstad-Minnihan,
  • Sriram Somasundaram,
  • Sashi Ayyangar,
  • Mark M. Davis,
  • Lawrence J. Stern,
  • Elizabeth D. Mellins

DOI
https://doi.org/10.1038/s41467-019-13234-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 17

Abstract

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T cells from narcolepsy patients were recently reported to recognize hypocretin, a wakefulness-promoting neurohormone, suggesting autoimmune origin of the disease. Here the authors show that hypocretin-specific T cells expand both in healthy controls and in narcolepsy patients, and identify preliminary features that may distinguish them.