Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

Beata Jablonska; Katrina L. Adams; Panagiotis Kratimenos; Zhen Li; Emma Strickland; Tarik F. Haydar; Katharina Kusch; Klaus-Armin Nave; Vittorio Gallo

doi:10.1038/s41467-022-32462-2

Nature Communications (Aug 2022)

Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

Beata Jablonska,
Katrina L. Adams,
Panagiotis Kratimenos,
Zhen Li,
Emma Strickland,
Tarik F. Haydar,
Katharina Kusch,
Klaus-Armin Nave,
Vittorio Gallo

Affiliations

Beata Jablonska: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Katrina L. Adams: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Panagiotis Kratimenos: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Zhen Li: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Emma Strickland: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Tarik F. Haydar: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Katharina Kusch: Max Planck Institute of Experimental Medicine, Department of Neurogenetics
Klaus-Armin Nave: Max Planck Institute of Experimental Medicine, Department of Neurogenetics
Vittorio Gallo: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital

DOI: https://doi.org/10.1038/s41467-022-32462-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Neonatal hypoxia leads to white matter hypomyelination due to delayed oligodendrocyte maturation. The authors identify Sirt2 as a crucial regulator of oligodendrocyte differentiation during normal white matter development and in response to hypoxia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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