Nature Communications (Apr 2020)

High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation

  • Wei He,
  • Jinzhi Xu,
  • Ruoyu Mu,
  • Qiu Li,
  • Da-lun Lv,
  • Zhen Huang,
  • Junfeng Zhang,
  • Chunming Wang,
  • Lei Dong

DOI
https://doi.org/10.1038/s41467-020-15524-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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High-salt intake can promote pro-inflammatory responses associated with pathological conditions. However, here, the authors show that high-salt diet may have an antitumor protective role by modulating the accumulation and phenotype of myeloid derived suppressor cells and enhancing immunosurveillance.