Nature Communications (Feb 2016)
Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour
- Masao Doi,
- Iori Murai,
- Sumihiro Kunisue,
- Genzui Setsu,
- Naohiro Uchio,
- Rina Tanaka,
- Sakurako Kobayashi,
- Hiroyuki Shimatani,
- Hida Hayashi,
- Hsu-Wen Chao,
- Yuuki Nakagawa,
- Yukari Takahashi,
- Yunhong Hotta,
- Jun-ichirou Yasunaga,
- Masao Matsuoka,
- Michael H. Hastings,
- Hiroshi Kiyonari,
- Hitoshi Okamura
Affiliations
- Masao Doi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Iori Murai
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Sumihiro Kunisue
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Genzui Setsu
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Naohiro Uchio
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Rina Tanaka
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Sakurako Kobayashi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Hiroyuki Shimatani
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Hida Hayashi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Hsu-Wen Chao
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Yuuki Nakagawa
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Yukari Takahashi
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Yunhong Hotta
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- Jun-ichirou Yasunaga
- Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Sakyo-ku
- Masao Matsuoka
- Laboratory of Virus Control, Institute for Virus Research, Kyoto University, Sakyo-ku
- Michael H. Hastings
- Division of Neurobiology, Medical Research Council Laboratory of Molecular Biology
- Hiroshi Kiyonari
- Animal Resource Development Unit and Genetic Engineering Team, RIKEN Center for Life Science Technologies
- Hitoshi Okamura
- Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku
- DOI
- https://doi.org/10.1038/ncomms10583
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 13
Abstract
The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits.
