Nature Communications (Jun 2019)
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns
- Darina Czamara,
- Gökçen Eraslan,
- Christian M. Page,
- Jari Lahti,
- Marius Lahti-Pulkkinen,
- Esa Hämäläinen,
- Eero Kajantie,
- Hannele Laivuori,
- Pia M. Villa,
- Rebecca M. Reynolds,
- Wenche Nystad,
- Siri E. Håberg,
- Stephanie J. London,
- Kieran J. O’Donnell,
- Elika Garg,
- Michael J. Meaney,
- Sonja Entringer,
- Pathik D. Wadhwa,
- Claudia Buss,
- Meaghan J. Jones,
- David T. S. Lin,
- Julie L. MacIsaac,
- Michael S. Kobor,
- Nastassja Koen,
- Heather J. Zar,
- Karestan C. Koenen,
- Shareefa Dalvie,
- Dan J. Stein,
- Ivan Kondofersky,
- Nikola S. Müller,
- Fabian J. Theis,
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium,
- Katri Räikkönen,
- Elisabeth B. Binder
Affiliations
- Darina Czamara
- Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry
- Gökçen Eraslan
- Institute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health
- Christian M. Page
- Oslo Centre for Biostatistics and Epidemiology, Research Support Unit, Oslo University Hospital
- Jari Lahti
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Marius Lahti-Pulkkinen
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Esa Hämäläinen
- HUSLAB and Department of Clinical Chemistry, Helsinki University
- Eero Kajantie
- Oulu University Hospital and University of Oulu, PEDEGO Research Unit
- Hannele Laivuori
- Medical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital
- Pia M. Villa
- Medical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital
- Rebecca M. Reynolds
- British Heart Foundation Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh
- Wenche Nystad
- Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health
- Siri E. Håberg
- Center for Fertility and Health, Norwegian Institute of Public Health
- Stephanie J. London
- Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services
- Kieran J. O’Donnell
- Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University
- Elika Garg
- Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University
- Michael J. Meaney
- Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University
- Sonja Entringer
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology
- Pathik D. Wadhwa
- University of California, Irvine, Development, Health, and Disease Research Program
- Claudia Buss
- Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology
- Meaghan J. Jones
- Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children’s Hospital Research Institute
- David T. S. Lin
- Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children’s Hospital Research Institute
- Julie L. MacIsaac
- Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children’s Hospital Research Institute
- Michael S. Kobor
- Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and the BC Children’s Hospital Research Institute
- Nastassja Koen
- Department of Psychiatry and Mental Health, University of Cape Town
- Heather J. Zar
- Department of Paediatrics & Child Health and SAMRC Unit on Child and Adolescent Health, University of Cape Town
- Karestan C. Koenen
- Department of Epidemiology, Harvard T. H. Chan School of Public Health
- Shareefa Dalvie
- Department of Psychiatry and Mental Health, University of Cape Town
- Dan J. Stein
- Department of Psychiatry and Mental Health, University of Cape Town
- Ivan Kondofersky
- Institute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health
- Nikola S. Müller
- Institute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health
- Fabian J. Theis
- Institute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health
- Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
- Institute for Molecular Bioscience, The University of Queensland
- Katri Räikkönen
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki
- Elisabeth B. Binder
- Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry
- DOI
- https://doi.org/10.1038/s41467-019-10461-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 18
Abstract
Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.
