Nature Communications (Jul 2019)

The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation

  • Eric Peterman,
  • Paulius Gibieža,
  • Johnathon Schafer,
  • Vytenis Arvydas Skeberdis,
  • Algirdas Kaupinis,
  • Mindaugas Valius,
  • Xavier Heiligenstein,
  • Ilse Hurbain,
  • Graca Raposo,
  • Rytis Prekeris

DOI
https://doi.org/10.1038/s41467-019-10871-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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The midbody is a structure found between the two dividing daughter cells that recruits regulators during cell division, but its role after cell division is poorly understood. Here, the authors find that midbodies can be internalized and send out intracellular signals to stimulate cell proliferation.