Nature Communications (May 2022)

Stochastic expression of invasion genes in Plasmodium falciparum schizonts

  • Jaishree Tripathi,
  • Lei Zhu,
  • Sourav Nayak,
  • Michal Stoklasa,
  • Zbynek Bozdech

DOI
https://doi.org/10.1038/s41467-022-30605-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

Genetically identical cells can be phenotypically diverse to allow adaptive flexibility in a given environment. This phenotypic diversity is driven by epigenetic and transcriptional variability. Here, Tripathi et al. perform scRNA-seq of isogenic and non-isogenic Plasmodium falciparum schizont populations to explore transcriptional heterogeneity and stochastic gene expression during the course of development.