Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Philip R. Jansen; Mats Nagel; Kyoko Watanabe; Yongbin Wei; Jeanne E. Savage; Christiaan A. de Leeuw; Martijn P. van den Heuvel; Sophie van der Sluis; Danielle Posthuma

doi:10.1038/s41467-020-19378-5

Nature Communications (Nov 2020)

Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence

Philip R. Jansen,
Mats Nagel,
Kyoko Watanabe,
Yongbin Wei,
Jeanne E. Savage,
Christiaan A. de Leeuw,
Martijn P. van den Heuvel,
Sophie van der Sluis,
Danielle Posthuma

Affiliations

Philip R. Jansen: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Mats Nagel: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Kyoko Watanabe: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Yongbin Wei: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Jeanne E. Savage: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Christiaan A. de Leeuw: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Martijn P. van den Heuvel: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Sophie van der Sluis: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam
Danielle Posthuma: Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam

DOI: https://doi.org/10.1038/s41467-020-19378-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Brain volume and intelligence have been previously found to have shared genetic etiology, but the specific common genetic signals have not been identified. Here, the authors perform a genome-wide association study on brain volume, finding common genetic loci driving brain volume and intelligence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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