Advanced Black Phosphorus Nanomaterials for Bone Regeneration

Abstract

Yun’an Qing, Ruiyan Li, Shihuai Li, Yuehong Li, Xingyue Wang, Yanguo Qin Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of ChinaCorrespondence: Yanguo QinOrthopaedic Medical Center, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, People’s Republic of ChinaTel [phone]Email [email protected]: Bone regeneration remains a great clinical challenge. Two-dimensional materials, especially graphene and its derivative graphene oxide, have been widely used for bone regeneration. Since its discovery in 2014, black phosphorus (BP) nanomaterials including BP nanosheets and BP quantum dots have attracted considerable scientific attention and are considered as prospective graphene substitutes. BP nanomaterials exhibit numerous advantages such as excellent optical and mechanical properties, electrical conductivity, excellent biocompatibility, and good biodegradation, all of which make them particularly attractive in biomedicine. In this review, we comprehensively summarize recent advances of BP-based nanomaterials in bone regeneration. The advantages are reviewed, the different synthesis methods of BP are summarized, and the applications to promote bone regeneration are highlighted. Finally, the existing challenges and perspectives of BP in bone regeneration are briefly discussed.Keywords: 2D materials, black phosphorus nanomaterials, bone regeneration, nanomedicine  

Keywords

• 2d materials
• black phosphorus nanomaterials
• bone regeneration
• nanomedicine.