Terpenoids and Steroids from Trichilia Species

Abstract

The methanol extract of stems of Trichilia claussenii yielded three new sesquiterpenoids: 14-hydroxyelemol, germacra-10(14)-en-9,11,15-triol and germacra-3,10(14)-dien-9,11-diol-4-carbaldehyde. Two known sesquiterpenoids beta-eudesmol, cryptomeridiol and the triterpenoid 22,25-dihydroxy-9beta,19-cyclolanost-23-en-3-one were also isolated. The dichloromethane extract from the leaves of T. lepidota afforded a mixture of hydrocarbons (C29H60, C31H64 and C33H68), a mixture of the sesquiterpenes caryophyllene and humulene epoxides, spathulenol, and a series of sterols: 24-methylene-12b-hydroxycholesterol, 24-methyl-12beta-hydroxycholest-4-en-3-one, 24-methylene-12beta-hydroxycholest-5-ene-3-palmitate; a mixture of 24-methylenecholesterol, campesterol, stigmasterol and beta-sitosterol; besides alpha-tocoferol and phytol. From the methanol extract it was isolated N-methyl-4-hydroxyproline. The structures of the isolated compounds were determined on the basis of spectroscopic analysis.

Keywords

• Trichilia claussenii
• Trichilia lepidota
• Meliaceae
• sesquiterpenoids
• cycloartane triterpenoid
• steroids