Chronic obstructive pulmonary disease in non-smokers: role of oxidative stress

Abstract

Abstract Background A striking feature of chronic obstructive pulmonary disease (COPD) is its inability to resolve after cigarette smoke exposure has ended, which has contributed to the possibility that the disease could also be driven by other endogenous causes, such as autoimmunity or chronic infection. The objective of this research was to examine oxidative stress in non-smoker and ex-smoker COPD subjects and its relationship to pulmonary functions and sputum cytology. Results This case control-study enrolled 40 patients with COPD who are non-smokers or ex-smokers and 30 healthy controls of non-smokers or ex-smokers; oxidative stress markers, superoxide dismutase (SOD), and malondialdehyde (MDA) were compared in the two groups. All oxidative stress markers are elevated in the COPD group versus the control group. MDA has a negative correlation with FEV1and dyspnea grade. Conclusion Blood concentrations of SOD and MDA are consistently higher in patients with non-smokers or ex-smoker COPD when compared to non-smokers or ex-smoker healthy controls.

Keywords

• COPD
• Oxidative stress
• Superoxide dismutase
• Malondialdehyde