Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

Abstract

New four eunicellin-based diterpenoids, krempfielins J–M (1–4) were isolated from the organic extract of a Taiwanese soft coral Cladiella krempfi. The structures of the new metabolites were elucidated on the basis of extensive spectroscopic analysis. The structure of compound 2 is rare due to the presence of the highly oxygenated pattern. Anti-inflammatory activity of 1–6 to inhibit the superoxide anion generation and elastase release in FMLP/CB-induced human neutrophils was also evaluated, and 2 and 4 were shown to possess the ability to inhibit the elastase release.

Keywords

• Cladiella krempfi
• eunicellin-based diterpenoid
• elastase
• anti-inflammatory agent