The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Go Eun Ha; Jaekwang Lee; Hankyul Kwak; Kiyeong Song; Jea Kwon; Soon-Young Jung; Joohyeon Hong; Gyeong-Eon Chang; Eun Mi Hwang; Hee-Sup Shin; C. Justin Lee; Eunji Cheong

doi:10.1038/ncomms13791

Nature Communications (Dec 2016)

The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons

Go Eun Ha,
Jaekwang Lee,
Hankyul Kwak,
Kiyeong Song,
Jea Kwon,
Soon-Young Jung,
Joohyeon Hong,
Gyeong-Eon Chang,
Eun Mi Hwang,
Hee-Sup Shin,
C. Justin Lee,
Eunji Cheong

Affiliations

Go Eun Ha: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
Jaekwang Lee: Center for Neural Science, Korea Institute of Science and Technology
Hankyul Kwak: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
Kiyeong Song: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
Jea Kwon: Center for Neural Science, Korea Institute of Science and Technology
Soon-Young Jung: Center for Neural Science, Korea Institute of Science and Technology
Joohyeon Hong: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
Gyeong-Eon Chang: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University
Eun Mi Hwang: Center for Functional Connectomics, Korea Institute of Science and Technology
Hee-Sup Shin: Center for Cognition and Sociality, Institute for Basic Science
C. Justin Lee: Center for Neural Science, Korea Institute of Science and Technology
Eunji Cheong: Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University

DOI: https://doi.org/10.1038/ncomms13791
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Spike-frequency adaptation in thalamocortical (TC) neurons is important for sensory transmission though the underlying mechanisms are not fully understood. Here, the authors identify a role for the calcium-activated chloride channel, ANO2, in mediating TC spiking adaptations and visceral pain response.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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