Communications Biology (Sep 2021)

Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer

  • Julian Budzinski,
  • Simone Maschauer,
  • Hiroyuki Kobayashi,
  • Pierre Couvineau,
  • Hannah Vogt,
  • Peter Gmeiner,
  • Anna Roggenhofer,
  • Olaf Prante,
  • Michel Bouvier,
  • Dorothee Weikert

DOI
https://doi.org/10.1038/s42003-021-02574-4
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

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Budzinski et al use bivalent ligands, BRET assays and radioligand competition to demonstrate a specific interaction between two receptors associated with neuropsychiatric diseases and addiction, dopamine D3 (D3R) and neurotensin receptor 1. They show that the bivalent ligands promote endosomal trafficking of D3R, suggesting a potential role for dimerization in vivo.