EFFECT OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) IN COMPARISON WITH BASIS STRUCTURAL COMPOUNDS ON SOME PROTEIC METABOLISM PARAMETERS IN RATS

Abstract

The aim of the study was to relieve the effect of synthesis product (by-product of salicylic acid) administration 5-cloro-2hidroxy-azotil-sulfamoil-fenil benzamide (5ClSA-SA) in comparison with basic structural compounds (salicylamide and sulfanilamide) on some parameters of proteic metabolism on rats. The synthesis product 5ClSA-SA is amide of 5 chlorosalycilic acid with sulfanilamide synthesized at The Technical University, Faculty of Industrial Chemistry of Timisoara. The experimental results demonstrate that the synthesis product has determinate a strong significant increase (p0.05) of creatinine compared to test, obtained values being situated in physiological limits, while salicylamide and sulfanilamide have induced strong significant decrease (p>0.01), respectively significant (p>0.05) compared to test and under physiological limits.

Keywords

• protein
• albumin
• urea
• creatinine
• rat