Impact of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio on the risk factors for and outcome of ischemic stroke

Abstract

This paper aims to investigate the relationship between the ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) and risk factors for acute ischemic stroke, and to investigate the effect of LDL-C/HDL-C on the 3-month outcome of acute ischemic stroke. Based on baseline characteristics and laboratory data on admission, 150 patients with non?cardiac acute ischemic stroke were divided into 2 groups (LDL-C/HDL-C ≤ 3 and LDL-C/HDL-C > 3). The outcome of 3 months after stroke was analyzed, and the risk factors were compared between 2 groups. There was significant difference in history of diabetes, history of coronary artery disease, history of smoking and atherosclerotic lesions between 2 groups (P < 0.05, for all). After using multifactor stepwise Logistic regression analysis, only the LDL-C/HDL-C ratio > 3 (OR = 1.781, 95%CI: 1.343-2.374; P = 0.001) and National Institute of Health Stroke Scale (NIHSS) score on admission (OR = 1.923, 95%CI: 1.232-5.944; P = 0.032) were significantly and independently predictive for 3-month outcome. Therefore, the ratio of LDL-C to HDL-C serves as a positive predictor of the 3-month clinical outcome of acute ischemic stroke. doi: 10.3969/j.issn.1672-6731.2014.10.014

Keywords

• Stroke
• Lipoproteins, LDL
• Lipoproteins, HDL
• Hyperlipidemias
• Risk factors
• Regression analysis