In ovo administration of CpG ODN induces expression of immune response genes in neonatal chicken spleen

Abstract

Introduction: Due to their immunostimulatory properties TLR ligands are used prophylactically to protect against a variety of viral and bacterial pathogens in mammals. Knowledge of the molecular and functional aspects of TLRs is essential for a better understanding of the immune system and resistance to diseases in birds. For that reason, this study attempted to determine the impact of TLR21 stimulation by its synthetic ligand (CpG ODN, class B) on the chicken immune system.

Keywords

• chicken
• chtlr21
• cpg odn
• immunomodulation
• cytokines