Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles

Yanfei Wang; Chi-Hsiu Liu; Tianjiao Ji; Manisha Mehta; Weiping Wang; Elizabeth Marino; Jing Chen; Daniel S. Kohane

doi:10.1038/s41467-019-08690-4

Nature Communications (Feb 2019)

Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles

Yanfei Wang,
Chi-Hsiu Liu,
Tianjiao Ji,
Manisha Mehta,
Weiping Wang,
Elizabeth Marino,
Jing Chen,
Daniel S. Kohane

Affiliations

Yanfei Wang: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Chi-Hsiu Liu: Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School
Tianjiao Ji: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Manisha Mehta: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Weiping Wang: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Elizabeth Marino: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School
Jing Chen: Department of Ophthalmology, Boston Children’s Hospital, Harvard Medical School
Daniel S. Kohane: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-08690-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Current treatments of wet age-related macular degeneration require repeated injections of active drugs into the vitreous. Here Wang et al. develop nanoparticles that when injected intravenously can be targeted to the eye by irradiation with blue light, allowing local and enhanced drug release in the back of the eye, and providing an alternative to current delivery strategies.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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