Assessment of cardiac hemodynamics indicators in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor A1166C gene polymorphism

Abstract

Aim of study is to estimate the indicators of cardiac hemodynamics in patients with arterial hypertension and non-alcoholic fatty liver disease depending on angiotensin II type 1 receptor (A1166C) gene polymorphism. Materials and methods. 55 patients with arterial hypertension and non-alcoholic fatty liver disease were comprehensively examined. The study of angiotensin II type 1 receptor (A1166C) gene polymorphism was carried out by means of the polymerase chain reaction method. Accuracy of genotype frequency distribution was assessed in accordance with the Hardy-Weinberg Equilibrium (pi2 + 2 pipj + pj2 = 1). Results. In the subgroup of patients with arterial hypertension and non-alcoholic fatty liver disease with the angiotensin II type 1 receptor gene (A1166C) C/C genotype the values of end-diastolic volume exceeded by 13.45 % and 28.31 %; the end-systolic volume –by 22.41 % and 39.09 %; the end-diastolic diameter – by 10.67 % and 38.95 %; the end systolic diameter – by 15.63 % and 29.11 %; the left ventricular mass – by 11.18 % and 19.38 %, whereas the ejection fraction was lower compared to patients with the A/C and A/A genotypes, respectively (p<0.05). According to our study results, no differences in left ventricular diastolic dysfunction were found depending on angiotensin II type 1 receptor (A1166C) gene polymorphism in the examined patients. Conclusions. The C allele of angiotensin II type 1 receptor (A1166C) gene polymorphism in patients with arterial hypertension and non-alcoholic fatty liver disease is associated with the heart morphofunctional changes, namely, hypertrophy progression, left ventricular cavity size and volume enlargement and decrease in myocardial contractility.

Keywords

• hemodynamics
• hypertension
• non-alcoholic fatty
• liver disease
• genetic polymorphism
• angiotensin II