Nature Communications (Jun 2016)

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

  • C. Colin Brinkman,
  • Daiki Iwami,
  • Molly K. Hritzo,
  • Yanbao Xiong,
  • Sarwat Ahmad,
  • Thomas Simon,
  • Keli L. Hippen,
  • Bruce R. Blazar,
  • Jonathan S. Bromberg

DOI
https://doi.org/10.1038/ncomms12021
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

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Lymphotoxin regulates lymphoid organ architecture and adhesion molecules involved in lymphocyte trafficking. Here the authors show that lymphotoxin produced by regulatory T cells promotes their migration to the draining lymph nodes by engaging its cognate receptor on lymphatic endothelial cells.