An Immune-Related lncRNA Signature to Predict the Biochemical Recurrence and Immune Landscape in Prostate Cancer

Abstract

Guian Zhang,1 Yong Luo2 1School of Medicine, South China University of Technology, Guangzhou, 510006, People’s Republic of China; 2Department of Urology, the Second People’s Hospital of Foshan, Affiliated Foshan Hospital of Southern Medical University, Foshan, 528000, People’s Republic of ChinaCorrespondence: Yong LuoDepartment of Urology, the Second People’s Hospital of Foshan, Affiliated Foshan Hospital of Southern Medical University, 78 Weiguo Road, Foshan, 528000, People’s Republic of ChinaTel [phone]Fax [phone]Email [email protected]: This study aims to construct an immune-related signature to provide comprehensive insights into the immune landscape of prostate cancer, which can predict biochemical recurrence (BCR) and clinical treatment.Methods: Based on The Cancer Genome Atlas (TCGA) dataset, a signature constructed by DEirlncRNAs pairs was determined. The receiver operating characteristic curve analysis, Kaplan–Meier analysis, nomogram, and decision curve analysis were used to analyze it. Then, immunophenoscore (IPS), immune cell infiltration, tumor mutation burden (TMB), and immune function were investigated. Finally, we evaluated the role of the signature in medical treatment.Results: A signature constructed by 10 valid DEirlncRNAs pairs was identified in the training set and validated well in the testing and entire set. The signature was a reliable and independent prognostic indicator to predict the BCR of prostate cancer, which was better than the clinicopathological characteristics. After dividing the patients into low- and high-risk groups by median value, we found that the high-risk group had shorter BCR-free time and higher TMB levels. Furthermore, the high-risk group was negatively associated with plasma B cells and CD+8 T cells. IPS and immune functions, such as immune checkpoints and human leukocyte antigen, were significantly different between the two groups. Low-risk group was more sensitive to endocrine therapy and immunotherapy, while high-risk group was more inclined to targeted drugs. Both groups had their own sensitive chemotherapy.Conclusion: We established a novel signature to predict BCR and validated its role in the immune landscape of prostate cancer, which could help patients receive personalized medical treatment.Keywords: prostate cancer, lncRNA, biochemical recurrence, TMB, immune landscape, medical treatment

Keywords

• prostate cancer
• lncrna
• biochemical recurrence
• tmb
• immune landscape
• medical treatment.